Identification and characterization of an emerging small ruminant lentivirus circulating recombinant form (CRF)
نویسندگان
چکیده
منابع مشابه
Study of compartmentalization in the visna clinical form of small ruminant lentivirus infection in sheep
BACKGROUND A central nervous system (CNS) disease outbreak caused by small ruminant lentiviruses (SRLV) has triggered interest in Spain due to the rapid onset of clinical signs and relevant production losses. In a previous study on this outbreak, the role of LTR in tropism was unclear and env encoded sequences, likely involved in tropism, were not investigated. This study aimed to analyze heter...
متن کاملSmall ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes
Small ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at great...
متن کاملMannose receptor may be involved in small ruminant lentivirus pathogenesis
Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3)...
متن کاملSmall ruminant lentivirus genotype E is widespread in Sarda goat.
The highly divergent SRLV genotype E has recently been characterized in Italy as a low pathogenic caprine lentivirus in the Roccaverano breed. The availability of a genotype specific diagnostic test based on a comparative assay, using a combination of genotype specific recombinant antigens allows a wide serosurvey in other goat populations. The island of Sardinia still has the highest small rum...
متن کاملAn insight into a combination of ELISA strategies to diagnose small ruminant lentivirus infections.
A single broadly reactive standard ELISA is commonly applied to control small ruminant lentivirus (SRLV) spread, but type specific ELISA strategies are gaining interest in areas with highly prevalent and heterogeneous SRLV infections. Short (15-residue) synthetic peptides (n=60) were designed in this study using deduced amino acid sequence profiles of SRLV circulating in sheep from North Centra...
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ژورنال
عنوان ژورنال: Virology
سال: 2015
ISSN: 0042-6822
DOI: 10.1016/j.virol.2014.11.006